• VOD-new-1
  • linkedin

Does a powder containment hood – not an ISO 5 hood – used for sterile compounding have to be externally vented?

No. Assuming the powder containment hood is for the non-sterile preparation of a sterile compound, it can be vented into the room via redundant HEPA filtration. The hood is still required to be in a C-SEC, which is vented to the outside.

API Active pharmaceutical ingredient
CACI Compounding aseptic containment isolator
C-PEC Containment primary engineering control
C-SEC Containment secondary engineering control
HD Hazardous drug
HEPA High-efficiency particulate air
NIOSH National Institute for Occupational Safety and Health
SOP Standard operating procedure


  1. US Pharmacopeial Convention. (2016). Frequently Asked Questions: <800> Hazardous Drugs—Handling in Healthcare Settings. Retrieved from http://www.usp.org/frequently-asked-questions/hazardous-drugs-handling-healthcare-settings