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If my pharmacy is not compounding hazardous drugs, do we need a negative-pressure room or negative-pressure hood?

No. However, we recommend that you fully review the National Institute for Occupational Safety and Health (NIOSH) list to ensure your pharmacy is not compounding anything on the list. Some states may require all compounding to take place under a powder containment hood. Make sure to review your state’s rules and regulations to ensure compliance.

API Active pharmaceutical ingredient
CACI Compounding aseptic containment isolator
C-PEC Containment primary engineering control
C-SEC Containment secondary engineering control
HD Hazardous drug
HEPA High-efficiency particulate air
NIOSH National Institute for Occupational Safety and Health
SOP Standard operating procedure


  1. US Pharmacopeial Convention. (2016). Frequently Asked Questions: <800> Hazardous Drugs—Handling in Healthcare Settings. Retrieved from http://www.usp.org/frequently-asked-questions/hazardous-drugs-handling-healthcare-settings